The drug has been developed by Orion Pharma. Description Chemical name (RS)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole. It is a sedative that provides pain relief as well as muscle relaxation. NADA #140-999, Approved by FDA. This invention relates to the use of certain salts of medetomidine and its optically active enantiomers, particularly its d-en-antiomer to regulate the rate of the transdermal administration of the drugs. Possibly Marketed Outside US Source: Canada:MEDETOMIDINE HYDROCHLORIDE Physical properties. 118 L; Protein binding. Absorption Not Available Volume of distribution. Safety. Drug Label Info. Lipophilic salts combined with hydrophilic vehicles or hydrophilic salts combined with lipophilic vehicles exhibit good permeation. Browse Drug Classes; Labeling Archives; Label: MEDETOMIDINE HYDROCHLORIDE powder. 2. ATOM 15 1 C8y C 21.2800 -17.9200 2 C8x … MED'COM, 208 - 209. Label RSS; Share Bookmark & Share. a) Classification i) Developed initially as a human antiviral drug, also used to treat Parkinson’s disease b) General Information However, … Metabolism. The pharmacology of these drugs has been reviewed in current anesthesia and pharmacology texts and, in the case of medetomidine, in a supplement to Acta Veterinaria Scandinavica, 85, 1989, to which the interested reader is referred. Moving onto another class of sedative drug, here are 5 benefit of using an alpha 2 adrenergic receptor antagonist as part of your anaesthetic regime in healthy animals. Physical properties. Description Domitor (medetomidine hydrochloride) is a synthetic α2-adrenoreceptor agonist with … DRUG: Medetomidine: Help: Entry: D08165 Drug : Name ... Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Adrenaline ADRA2 D08165 Medetomidine (INN) BRITE hierarchy: Other DBs: CAS: 86347-14-0: PubChem: 96024855: ChEMBL: CHEMBL77921: LigandBox: D08165: NIKKAJI: J134.038G: KCF data: Show. 6 th Ed., Iowa: Blackwell Publishing, 2008, page 363.. Effets secondaires. Cl 3 H 16 N 2. In the United States, it is currently approved for its veterinary use in dogs and distributed by Pfizer Animal Health. Topic. D Drugs : Alphabetical Drug Summaries : Dr. Bob Stein : 1) DERACOXIB a) Classification i) A coxib class COX2 selective NSAID. Portail de la chimie; Portail de la médecine; Portail de la pharmacie; La dernière modification de cette page a été faite le 13 septembre 2020 à 21:17. It is the next generation of opioid immobilisation drugs, which is claimed to induce more rapid immobilisation and shorter duration of action compared to etorphine (Lance & Kenny 2012). Antisedan Caution . Medetomidine, commonly known by the brand name Dormitor, is an injectable drug used for sedation in dogs and cats. Medetomidine: Last updated: 18/02/2021 (Not known by any other names) GENERAL INFORMATION: Description: Used as an antifouling substance in marine paint and as a general anaesthetic as a sedative and analgesic drug for a variety of animals. Cardiovascular effects include vasoconstriction , decreased heart rate (by 40%) and cardiac output (by … ATOM 15 1 C8y C 21.2800 … Route of elimination. (2016) Propofol-medetomidine-ketamine total intravenous anesthesia ... PROPOFOL: When propofol is used after medetomidine, hypoxemia may occur. Torbugesic Injection should be administered at 0.1 ml/10 kg bodyweight (equivalent to 0.1 mg butorphanol/kg) together with 0.1–0.25 ml Domitor™/10 kg bodyweight (equivalent to 10–25 μg medetomidine/kg) depending on degree of sedation required, both by intramuscular or intravenous injection. Medetomidine is an intravenously available alpha-2 adrenergic agonist. This article is available in full to registered subscribers. This is a quick intro lecture to review the concept of the adrenergic agonists. These drugs provide reliable dose-dependent sedation. The Misuse of Drugs Regulations 2001 (and subsequent amendments) defines the classes of person who are authorised to supply and possess Controlled Drugs while acting in their professional capacities and lays down the conditions under which these activities may be carried out. HCl. Correspondingly, medetomidine caused a significantly greater increase in plasma glucose concentrations in the WT than in the CD38-/-mice. Description. Class of drug. DRUG: Medetomidine hydrochloride: Help: Entry: D04883 Drug : Name: Medetomidine hydrochloride (USAN) Formula: C13H16N2. Medetomidine belongs to a class of drugs known as alpha 2 adrenergic agonists and is similar to clonidine and xylazine. The alpha-2-adrenoreceptor agonist, medetomidine, which exhibits dose-dependent sedative effects and is gaining acceptance in small-animal functional magnetic resonance imaging (fMRI), has been studied. A mass balance study demonstrated that after nine days an average of 95% of the radioactivity, following intravenous administration of radiolabeled dexmedetomidine, was recovered in the urine and 4% in the feces. Drugs in this group include detomidine, romifidine and several others, but the most frequently used in rats are xylazine and medetomidine. VERWAERDE P., ESTRADE C. Vade-mecum d'anesthésie des Carnivores domestiques. Expired - Lifetime Application number EP87309984A Other languages German (de) English (en) Other versions EP0270267A3 (en … b) General Information i) Effective anti-inflammatory/analgesic generally free of significant GI side effects. analogue (of the 4-anilidopiperidine opioid class) and, like fentanyl, has an exclusive affinity for the mu-opioid receptor (Vardanyan & Hruby 2014). Exact mass: 236.108. The most commonly used drugs in this class are medetomidine and dexmedetomidine in small animals & xylazine, detomidine, medetomidine and romifidine in horses. The chemical name is 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride. Sedative and Analgesic. Dexmedetomidine and Medetomidine Reversing Agent. Conclusion: The CD38/cADPR signaling pathway may be one underlying mechanism of the glucose and insulin effects of the alpha-2 adrenergic receptor agonist medetomidine and likely other drugs of its' class. Medetomidine is a synthetic drug used as both a surgical anesthetic and analgesic. Rats were examined on the bench using the classic tail-pinch method with three infusion sequences: 100 microg/kg/h, 300 microg/kg/h, or 100 microg/kg/h followed by 300 microg/kg/h. Molecular formula. Hepatic. It is an α2 adrenergic agonist that can be administered as an intravenous drug solution with sterile water. 200.28. ANTISEDAN (atipamezole hydrochloride) is a synthetic α 2-adrenergic antagonist. Browse Drug Classes; Labeling Archives; Advanced Search; View More. Medetomidine: Last updated: 18/02/2021 (Not known by any other names) GENERAL INFORMATION: Description: Used as before a general anaesthetic as a sedative and analgesic drug for a variety of animals. 2005, Éd. DRUG: Medetomidine: Help: Entry: D08165 Drug : Name ... Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Adrenaline ADRA2 D08165 Medetomidine (INN) BRITE hierarchy: Other DBs: CAS: 86347-14-0: PubChem: 96024855: ChEMBL: CHEMBL77921: LigandBox: D08165: NIKKAJI: J134.038G: LinkDB: All DBs: KCF data: Show. Synthetic drug used as both a surgical anesthetic and analgesic. Alpha-2 adrenergic agonist. Access your plan list on any device – mobile or desktop. Individual plans may vary and formulary information changes. For intramuscular use in dogs only. or butorphanol-azaperone-medetomidine and atipamezole reversal. The above information is provided for general informational and educational purposes only. 94%. Storage requirements. Protect from light. View Package Photos. It is also used as a stand alone tranquiliser for brief non-traumatic surgery and as a sedative for fractious or nervous cats. Description Chemical name. J Zoo Wild Med 46(2):291-297. v) Boardman WS, Lethbridge MR, Hampton JO, Dosages; Dosage Forms; Drug Interactions; Adverse Effects ; Veterinary Medication Guide; Alfaxalone. La dexmédétomidine provoque une dépression cardio-respiratoire importante à l'origine d'une bradycardie sinusale, de blocs auriculo-ventriculaires et d'une bradypnée dose-dépendantes. Source : PLUMB D.C. Veterinary Drug Handbook. Medetomidine. Molecular formula. Class of drug. (medetomidine hydrochloride) Sterile Injectable Solution-1.0 mg/mL. Storage requirements <25°C. Topics similar to or like Medetomidine. c) Advantages/Recommended use Mol weight: 236.7405. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Medetomidine is similar to these topics: Atipamezole, Butorphanol, Ketamine and more. A process of preparing Medetomidine of Formula (I) or an acid addition salt thereof, which process comprises: (i) reacting 2,3-dimethyl-methylbenzylalcohol with N-trimethylsilylimidazole, and, if desired, converting the Medetomidine to an acid addition salt thereof. Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. Drug dosages used for premedication should be tailored to the individual cat. Atipamezole. An aqueous solution. Contact the applicable plan provider for the most current information. View explanations for tiers and restrictions. Medetomidine. It is soluble in water. 4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole. Wikipedia. Correspondingly, medetomidine caused a significantly greater increase in plasma glucose concentrations in the WT than in the CD38(-/-) mice. It is often used as the hydrochloride salt, medetomidine hydrochloride, a crystalline white solid. Molecular weight. Medetomidine belongs to a class of drugs known as alpha 2 adrenergic agonists and is similar to clonidine and xylazine. Domitor and Torbugesic may be combined and administered in the same syringe. MEDETOMIDINE MR15E85MQM Overview Structure Names 6: Classification 2: Identifiers 13: Relationships 3: Active Moiety 1: Audit Info References 16: History 1: Moieties 1: Substance Class: Chemical Record UNII: MR15E85MQM. Domitor Caution Federal law restricts this drug to use by or on the order of a licensed veterinarian. Federal law restricts this drug to use by or on the order of a licensed veterinarian. Medetomidine is a popular tranquiliser for use in cats prior to general anaesthesia. 6 th Ed., Iowa: Blackwell Publishing, 2008, 756 - 759. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Structure: Mol file KCF file DB search: Simcomp: Neighbor: Class: Cardiovascular agent DG01456 Adrenergic receptor agonist DG01450 alpha-Adrenergic receptor agonist DG01449 alpha2-Adrenergic receptor agonist DG01655 … Monograph Type: Systemic Drug; Drug Class: Alpha-2 Adrenergic Agonist; Trade Name: Domitor® LR, Stegmann GF, et al. Uses. Share. medetomidine drinking animals test anxiolytic Prior art date 1986-11-11 Legal status (The legal status is an assumption and is not a legal conclusion. Currently the most commonly used agents in this class are medetomidine and dexmedetomidine. The molecular … Classe thérapeutique Sédatif ... Veterinary Drug Handbook. For intramuscular and intravenous use in dogs only. Atipamezole is commonly used to treat horses and dogs, with extra-label use for other species. Alpha-2 adrenergic agonist. Compare formulary status to other drugs in the same class. C13H16N2. White or almost white crystalline substance. Medetomidine . Atipamezole is labeled by the U.S. Food and Drug Administration (FDA) for use as a reversal agent for medetomidine and dexmedetomidine in order to reduce their sedative and analgesic effects.